22nd December 2006 at 10:07 GMT by Dr C.A.Jenner MB BS, FRCA. Permalink.
Article on the indications, mechanisms and adverse effects of Pregabalin
Pregabalin (pre-GAB-a-lin) is an anticonvulsant drug prescribed for the management of neuropathic pain associated with diabetic peripheral neuropathy (DPN), post-herpetic neuralgia (PHN) and epilepsy.In laymen terms, Pregabalin is a drug prescribed for relief from the diabetic nerve pain and used as an adjunct therapy for epilepsy patients with partial seizures and for generalized anxiety disorders. Pregabalin is known to have a considerable impact on neuropathic lower back pain. Besides, an anticonvulsant is also known to reduce lower back pain with a considerably less amount of side effects than tricyclic antidepressants. Marketed by Pfizer under the trade name Lyrica®, Pregabalin was developed as a follow-up drug to gabapentin and works by preventing or controlling abnormal increases in the brain electrical activity. While the European Union approved the drug in 2004, the US Food and Drug Administration (FDA) gave the approval for use a year later, in 2005.
Certain factors could hamper the effect of Pregabalin or even become counter-productive. Before you start with medication, make it a point to discuss with your health care provider if any of the below is relevant to your situation:
The oral dosage of Pregabalin for adults is normally prescribed on the following patterns:
In case of a missed dose, the patient is advised to consume the same as soon as possible. However, if the dose is skipped altogether, the patient is advised to resume with his normal schedule and strictly directed not to double doses.
As per the clinical trials carried out by the FDA in more than 9000 patients, adverse effects of the pregabalin drug were found to be mild to moderate in most of the cases. Research classifies side effects into the following three types:
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